Tissue Engineering & Mechanobiology Mechanical Testing Solutions

Tissue engineering applies the principles of biology and engineering to the development of functional substitutes for damaged tissue. Mechanobiology provides insights into tissue physiology, disease development and relevant therapeutic strategies by understanding how mechanical forces induce changes at the molecular, cellular and tissue levels. These two fields focus heavily on how physical forces and changes in the mechanical properties of cells and tissues contribute to development, cell differentiation, physiology, and disease. Thus, mechanical testing is an integral part of advancements in these emerging fields.

ADMET testing systems are trusted by leading medical device manufacturers, universities, and research laboratories to determine the mechanical properties and endurance limits of medical devices, biomaterials, tissues, and tissue-engineered products. Our systems designed for tissue engineering and mechanobiology applications incorporate mechanical testing solutions that mimic the physiological conditions of the specimen. In addition, ADMET has become a world leader in miniature test systems that sit atop a microscope stage and fit inside perfusion bioreactors. These sophisticated miniature test systems help tissue engineers and cell biologists perform high resolution investigations in mechanobiology.

Why do scientists study the mechanical properties of tissues?

Mechanical properties of biological tissues serve as a cornerstone for advancements in healthcare technology, diagnostic techniques, and therapeutic approaches. Multiple applications in biomedical engineering, clinical diagnostics, and therapeutics rely on the comprehensive analysis of the mechanical properties of tissues. Below is a list of key reasons why scientists and engineers need to characterize these properties:

  • Physiological Insights
    • Mechanical properties can offer crucial insights into the physiological status of tissues. Changes in tissue stiffness or elasticity can be indicative of disease states such as fibrosis, cancer, or inflammation.
  • Biomechanics
    • Biomechanics, the field that establishes the mechanical properties of biological tissues such as bones, tendons, ligaments, and muscles, requires investigation and testing of biological tissues under various loading conditions. Although biomechanics applies engineering principles to biological systems, it also requires careful analysis of the biological tissue.
  • Implant Design
    • Knowledge of tissue mechanical properties is crucial for designing implants and prostheses that can mimic or complement the functions of natural tissues, thereby ensuring compatibility and reducing the risk of implant failure.
  • Regulatory Compliance
    • Understanding mechanical properties is often necessary to meet the regulatory standards that ensure the safety and efficacy of new medical devices and materials.
  • Tissue Engineering and Regeneration
    • For scientists involved in the development of artificial organs or tissues, understanding the mechanical properties is essential to create substitutes that behave similarly to natural tissues.
  • Personalized Medicine
    • As healthcare moves toward more personalized treatments, understanding the unique mechanical properties of an individual’s tissues can be essential for customized therapeutic approaches.
  • Drug Delivery
    • Mechanical properties can affect the diffusion of drugs in tissue, and thus influence drug delivery strategies. A more porous tissue may allow for quicker drug diffusion, while denser tissues might require specialized delivery mechanisms.
  • Diagnostics
    • Tools like elastography and other imaging technologies that assess tissue stiffness are becoming important diagnostic techniques for conditions like liver cirrhosis or tumors.
  • Surgical Planning
    • Surgeons can benefit from understanding tissue mechanical properties to make better judgments during operations. For example, the toughness of a tissue might influence the type of surgical tools used.
  • Computational Models
    • Accurate mechanical properties are essential for developing computational models of biological systems engineered to predict tissue behavior under various conditions.
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Why is it important to understand how cells respond to mechanical stimuli?

Understanding how cells respond to mechanical stimuli provides valuable insights into fundamental biological processes, facilitates advancements in medical research and technology, and leads the way for therapeutic interventions in various diseases. Below is a list of key reasons why scientists and engineers study the physical forces and changes in the mechanical properties of cells and tissues:

  • Regulation of Gene Expression
    • Mechanical forces can influence gene expression patterns. The field of mechanobiology studies how mechanical stimuli impact the regulation of genes. This understanding is crucial for unraveling the complexities of gene regulation and its connection to cellular function.
  • Drug Development
    • Many drugs and therapeutic interventions target cellular processes. If mechanical stimuli influence these processes, it becomes cru